Clinical features and treatment outcome of children with acute lymphoblastic leukemia and hyperleukocytosis

Abstract

Introduction: Hyperleukocytosis in children with acute lymphoblastic leukemia (ALL) has been associated with early morbidity and mortality. Clinical Case: We analyzed clinical data from 6 patients with ALL. We documented adverse events within the first 28 days in patients with a white blood cell (WBC) count ≥100 × 10(9)/l and reviewed their management. The most frequent biochemical alterations were hyperuricemia and hyperglycemia There were no severe complications or deaths. Conclusions: With improved management, including supportive care, early mortality in patients with ALL and hyperleukocytosis could be decreased remarkably.