Nitrated cyclic GMP as a new cellular signal

Abstract

Nitric oxide-mediated production of cyclic guanosine 3′,5′- monophosphate (cGMP) is a crucial signal transduction pathway that controls a wide array of biological functions. A new layer of complexity in mammalian cell regulation is revealed by the discovery of a redox-active nitrated cGMP derivative with the ability to post-translationally modify protein thiol residues by S-guanylation. © 2007 Nature Publishing Group.