Synthesis and characterization of magnetic composites: Intercalation of naproxen into Mg-Al layered double hydroxides coated on Fe 3O 4

Abstract

In this work the synthesis and characterization of a magnetic composite is described. It was prepared by deposition of Nap-Mg-Al-LDH on Fe 3O 4 by a coprecipitation method. The structures of the obtained products were studied by powder X-ray diffraction, FT-IR spectroscopy, elemental analysis, and thermogravimetric analysis. From the X-ray diffraction results, it was found that Fe 3O 4 was successfully distributed into the layered double hydroxide (LDH) phase. Furthermore, the increase in the basal spacing of LDHs from 0.881 nm to 2.157 nm shows that naproxen was successfully intercalated into the interlayer space. The particle size was estimated using transmission electron microscopy. Thermogravimetric studies indicate that the thermal stability of naproxen was enhanced after intercalation. Moreover, in vitro drug release experiments in phosphate buffer solution (pH = 7.4) were investigated. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.