Synthesis and biophysical studies of N2′-functionalized 2′-amino-α-L-LNA

Abstract

A synthetic route towards a selected set of N-acylated and N-alkylated derivatives of 2′-amino-α-L-LNA phosphoramidite building blocks has been developed. Biophysical studies suggest that the 2-oxo-5-azabicyclo[2.2.1] heptane skeleton of 2′-amino-α-L-LNA allows precise positioning of intercalators in the core of nucleic acid duplexes. Copyright © Taylor & Francis Group, LLC.