Development of cortical connections as measured by EEG coherence and phase delays

Abstract

The purpose of this study was to explore human development of EEG coherence and phase differences over the period from infancy to 16 years of age. The electroencephalogram (EEG) was recorded from 19 scalp locations from 458 subjects ranging in age from 2 months to 16.67 years. EEG coherence and EEG phase differences were computed for the left and right hemispheres in the posteriorto-anterior direction (O1/2-P3/4, O1/2-C3/4, O1/2-F3/4, and O1/2-Fp1/2) and the anterior-toposterior direction (Fp1/2-F3/4, Fp1/2-C3/4, Fp1/2-P3/4, and Fp1/2-O1/2) in the beta frequency band (13-25 Hz). Sliding averages of EEG coherence and phase were computed using 1 year averages and 9 month overlapping that produced 64 means from 0.44 years of age to 16.22 years of age. Rhythmic oscillations in coherence and phase were noted in all electrode combinations. Different developmental trajectories were present for coherence and phase differences and for anterior-to-posterior and posterior-to-anterior directions and inter-electrode distance. Large changes in EEG coherence and phase were present from ∼ 6 months to 4 years of age followed by a significant linear trend to higher coherence in short distance inter-electrode distances and longer phase delays in long inter-electrode distances. The results are consistent with a genetic model of rhythmic long term connection formation that occurs in cycles along a curvilinear trajectory toward adulthood. Competition for dendritic space, development of complexity, and nonlinear dynamic oscillations are discussed. © 2007 Wiley-Liss, Inc.