Association of AGTR1 gene A1166C polymorphism with the risk of heart failure: A meta-analysis

4Citations
Citations of this article
11Readers
Mendeley users who have this article in their library.

Abstract

The aim of this study was to investigate the correlation between the A1166C polymorphism in the angiotensin II type 1 receptor (AT1R) gene and heart failure (HF) risk using meta‑analysis. The PubMed database was searched, and data were extracted independently by two reviewers. Odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to assess the strength of the associations. Statistical analysis was performed using the STATA 12.0 software. The results of the meta‑analysis showed no significant association between the AT1R A1166C polymorphism and HF risk (AA vs CC: OR = 0.72, 95%CI = 0.31-1.68; AA vs AC: OR = 0.78, 95%CI = 0.52-1.18; dominant model: OR = 1.37, 95%CI = 0.92-2.04; recessive model: OR = 0.73, 95%CI = 0.30-1.75). In the subgroup analysis by ethnicity, the results also showed no significant association between A1166C polymorphism and susceptibility to HF in both Caucasian and Asian populations. In conclusion, this meta-analysis suggests that the A1166C polymorphism in AT1R may not be associated with susceptibility to HF. Further large and well-designed studies are needed to confirm these conclusions.

References Powered by Scopus

Effect of carvedilol on survival in severe chronic heart failure

2924Citations
N/AReaders
Get full text

Forecasting the future of cardiovascular disease in the United States: A policy statement from the American Heart Association

2605Citations
N/AReaders
Get full text

Lifetime risk for developing congestive heart failure: The Framingham Heart Study

1363Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Pharmacogenomics of heart failure: a systematic review

10Citations
N/AReaders
Get full text

AGTR1 rs3772622 gene polymorphism increase the risk of nonalcoholic fatty liver disease patients suffer coronary artery disease in Northern Chinese Han population

9Citations
N/AReaders
Get full text

Correlation between AT1R gene polymorphism and epilepsy secondary to cerebral infarction

7Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Zhang, J. A., Li, J. R., & Qiao, Y. J. (2015). Association of AGTR1 gene A1166C polymorphism with the risk of heart failure: A meta-analysis. Genetics and Molecular Research, 14(3), 9163–9170. https://doi.org/10.4238/2015.August.7.26

Readers over time

‘15‘16‘17‘18‘19‘20‘21‘2200.751.52.253

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 6

75%

Lecturer / Post doc 1

13%

Researcher 1

13%

Readers' Discipline

Tooltip

Medicine and Dentistry 3

43%

Biochemistry, Genetics and Molecular Bi... 2

29%

Computer Science 1

14%

Neuroscience 1

14%

Save time finding and organizing research with Mendeley

Sign up for free
0