Effect of high speed homogenizer speed on particle size of polylactic acid

Abstract

Polylactic acid (PLA) nanoparticles could provide extended release of drugs, reducing the frequency of injection and increasing the compliance diabetic retinopathy patients. This requires nanoparticles with a mean diameter of approximately 200 nm to facilitate penetration of small and narrow blood vessels in the retina. Mean diameter of PLA particles prepared using the emulsification-evaporation method was found to depend linearly on the speed of the high speed homogenizer, based on the data taken in the range of 1,000-10,000 rpm. PLA nanoparticles with a mean particle diameter of 190 nm with a spherical morphology could be obtained using a homogenizer speed of 10,000 rpm, allowing the use of PLA nanoparticles for extended release of drugs in the retina.