Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone

Abstract

Luongo and colleagues demonstrated that the two transporters of THs, MCT8 and OATP1C1, are required for adult SVZ-NSCs proliferation and determination toward a neuronal fate. Global knockout of both THTs maintained oligodendrogenesis at the expense of neurogenesis. These results showed that both THTs act as gate-keeper of NSC behavior, underlining the crucial role of these THTs during adult NSC determination.