Investigating the antimicrobial activity of 1-heteroaryl benzotriazole silver compounds

Abstract

Five (1-5) Ag(i) compounds, derived from different N,N′-bidentate 1-heteroaryl benzotriazole ligands, were synthesised and characterised using SXRD, IR, UV-Vis, elemental analysis, ESI-MS, and NMR. Variations in ligands and counter-anions produced distinct structures and morphologies. Preliminary antimicrobial testing at the micromolar level, in DMSO, revealed that only compound 2, based on 1-(2-pyridyl)benzotriazole and triflate anion, exhibited interesting antimicrobial properties, thus marking the introduction of a new class of Ag(i) compounds in medicinal inorganic chemistry.