MICO: A meta-tool for prediction of the effects of non-synonymous mutations

Abstract

The Next Generation Sequencing (NGS) is a state-of-the-art technology that produces high throughput data with high resolution mutation information in the genome. Numerous methods with different efficiencies have been developed to predict mutational effects in the genome. The challenge is to present the results in a balanced manner for better biological insights and interpretation. Hence, we describe a meta-tool named Mutation Information Collector (MICO) for automatically querying and collecting related information from multiple biology/bioinformatics enabled web servers with prediction capabilities. The predicted mutational results for the proteins of interest are returned and presented as an easy-to-read summary table in this service. MICO also allows for navigating the result from each website for further analysis. AVAILABILITY: http: //mico.ggc.org /MICO.