Synthesis and characterization of hollow mesoporous silica nanocomposites containing phosphorescent pigment and doxycycline

Abstract

Hollow mesoporous silica can be used as a carrier to store large amounts of drugs in pharmaceuticals due to its high surface area and suitable porosity. Therefore, the purpose of this study was to develop a SrAl 2 O 4 :Eu 2+ ,Dy 3+ hollow mesoporous silica and apply for loading and tracking of doxycycline (DOX) release. The structure and particle morphology were investigated by X‐ray diffraction (XRD), scanning and transmission electron microscopy (SEM and TEM) pictures, respectively. Photoluminescence (PL) spectra revealed that the phosphors had efficient luminescent and long‐lasting properties. Finally, according to the obtained results, the amount of drug loading in hollow mesoporous regular silica was 35% and the drug release from hollow mesoporous regular silica was gradual and controlled.