Pathogenicity analysis of klebsiella oxytoca isolated from larus ridibundus migratory birds

Abstract

Klebsiella oxytoca is one of the most common pathogens causing septicemia, pneumonia, and urinary tract infections in humans and animals and is a major concern for public health. In the present study, we aimed to elucidate the pathogenicity of K. oxytoca isolates obtained from Larus ridibundus using an in vivo system. The results revealed that the bacteria grew on EMB, lysogeny broth agar, MacConkey medium, nutrient broth, sheep blood agar, and Salmonella Shigella agar. K. oxytoca from L. ridibundus showed highest similarity (96.6%) to the reference strain (AB476819.1). Pathological biopsy revealed that K. oxytoca severely damaged hepatocytes, renal tubular epithelial cells, lymphocytes, and alveolar bronchioles in infected mouse tissues. The presence of this pathogen in L. ridibundus suggested that infectious diseases may be transmitted via pollution of water, allowing human infection to occur during the migration process. The findings will provide the foundation for the studies on the treatment of K. oxytoca.