A fast fluorimetric flow injection method to determine ibuprofen

Abstract

The native fluorescence of ibuprofen was enhanced when a host-guest complex of the analyte with β cyclodextrin (β-CD) was formed. So, based on this fact, a flow injection method to determine ibuprofen in different pharmaceutical preparations with fluorescence detection (λem 287 nm, λexc 223 nm) was developed. The calibration curve was linear over the range 6.00 -60.0 mg L-1 of ibuprofen and the detection limit (LOD) for S/N=3 was 4.5 mg L-1. The relative standard deviation was 1.2% and the sample throughput 240 h-1. The method was validated by comparing the proposed and the official method to commercial preparation samples. © 2006 Sociedade Brasileira de Química.