Synthesis and molecular docking studies of novel pyridine-thiazole-hydrazone conjugates as antimicrobial and antioxidant agents

Abstract

In the investigation, a series of new pyridyl and thiazolyl clubbed hydrazone derivatives have been synthesized. The newly synthesized compounds were evaluated for their in vitro antimicrobial and antioxidant activities. Some among the compounds have shown excellent antimicrobial activity against both bacterial and fungal pathogens. Two compounds among the series have exhibited excellent antioxidant activity. Furthermore, a molecular docking study has been performed against DNA gyrase to know the binding modes of these molecules and recorded good binding affinity. The ADME study has also been performed for predicting the pharmacokinetic profile, which expressed good oral drug-like behaviour.