Olanzapine-induced elevation of serum triglyceride levels in a normal weight patient with schizophrenia

Abstract

We encountered a case where treatment with olanzapine resulted in the elevation of serum triglyceride level despite the absence of weight gain and abnormal glucose metabolism. Elevation in serum triglyceride levels as seen in non-obese individuals does not fall under the category of metabolic syndrome which has recently been highlighted as an adverse reaction to second-generation, antipsychotics. In some individuals treated with antipsychotics, metabolic abnormalities develop with an initial sign of elevated serum triglyceride levels instead of weight gain. © 2008 The Japanese Society of Internal Medicine.