Histopathological Reactions of Calcium Phosphate Cement

Abstract

Calcium phosphate cement (CPC) consisting of Ca4 (P04)20 and CaHP04 (2H20) was recently developed. This studyevaluated in vivo aspects of CPC and CPC mixtures compared to those of commercial hydroxyapatite (HP) and several endodontic materials: Grossman's cement (GC), calcium hydroxide-iodine pste (CHP) and gutta-percha plate (GP).Biocompatibility of subcutaneous implants in Donryu rats was evaluated after onemonth. Results showed very slight inflammatory reactions from CPC, CPC mixtures and HP. The materials were surrounded by thin fibrous connective tissue with a small number of lymphocytes and plasma cells. Severe inflammatory reactions were provoked by GC. Granulation tissues induced by CHP resembled those of pseudoxanthomatous granuloma.The GP material was encapsulated by relatively thick fibrous connective tissues with little inflammatory reactions. © 1992, The Japanese Society for Dental Materials and Devices. All rights reserved.