Cbx4: A new guardian of p63's domain of epidermal control

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Abstract

Epigenetic regulators are essential for cell lineage choices during development. In this issue, Mardaryev et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506065) show that Polycomb subunit Cbx4 acts downstream of transcriptional regulator p63 to maintain epidermal progenitor identity and proliferation in the developing epidermis via Polycomb-dependent and -independent SUMO E3 ligase activities.

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Cohen, I., & Ezhkova, E. (2016, January 1). Cbx4: A new guardian of p63’s domain of epidermal control. Journal of Cell Biology. Rockefeller University Press. https://doi.org/10.1083/jcb.201512032

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