PBPK modeling advances understanding of D4 pharmacokinetics

Abstract

In summary, the biological determinants that are responsible for the unusual kinetic behavior of D4 remain to be elucidated empirically. However, the hypotheses generated by the PBPK kinetic analyses suggest plausible explanations for the kinetic behavior of D4. These authors have demonstrated with D4 that PBPK models can play an important role in discovery, in identification of experimental needs, and serve as a tool for hypothesis generation. Furthermore, the D4 research findings may be important for understanding the kinetic behavior of other chemicals that may behave similar to D4 such as selected hydrocarbons found in gasoline and jet fuels.