Sargassumilici folium (Turner) C. Agardh ameliorate oxidative stress induced neuronal degeneration in the Animal Model of Alzheimer's Disease

Abstract

Aluminium is a neurotoxic metal, exposure leads to neurodegenerative disease like Alzheimer's. Chronic exposure to it is a real eventuality due to its presence in food, air, water, in medicines and as floculating agents in water purification process. It is an important task to control its toxicity by natural source, so the present work aimed to investigate the neuroprotective activity of of Sargassumilicifolium against aluminium induction. Aluminium chloride of dose (100mg/kg b.wt) was given orally to induce cognitive dysfunction in rats. The ethanolic extract and ethyl acetate fraction of dose 100, 200, 400mg/kg and 200mg/kg respectively were selected and administered from 21st day of aluminium induction up to 40 days and in drug treated animals behavioural studies, antioxidant studies, neurotransmitter estimation and finally histopathological studies were performed. The study has revealed the potential neuro protective effect by improving the learning memory status in behavioural studies, reversing the stress induced free radicals and boosting the neurotransmitters level responsible for memory consolidation.