S‐100 protein in tumors of cartilage and bone: An immunohistochemical study

Abstract

Using the peroxidase‐antiperoxidase (PAP) immunohistochemical method, S‐100 protein was found in well‐differentiated chondrocytes of chondroma, chondroblastoma, mesenchymal chondrosarcoma, and osteosarcoma. It was not detected in osteoma, osteoblastoma, giant cell tumor, and Ewing's tumor. The presence of S‐100 protein in tumorous chondrocytes and chondroblasts suggests that this protein may be a marker of chondrocyte origin and should not be considered a specific marker for nerve tissue. Copyright © 1983 American Cancer Society