Potential impact of Panax ginseng against ethanol induced hyperlipidemia and cardiac damage in rats

Abstract

The objective of the current work was to explore the possible hypolipidemic and therapeutic impacts of Panax ginseng against cardiac damage in response to ethanol ingestion in male and female rats. 10% ethanol was ingested (2ml/Kg) to both male and female rats daily for fourteen days. The results showed that ingestion of ginseng (150mg/Kg) daily for six weeks to male and female rats intoxicated with ethanol, two weeks after ethanol ingestion, successfully modulated the alterations in the serum lipid profiles, namely, triglycerides (TGs), total cholesterol (TCh), low density lipoprotein (LDL-C) and high density lipoprotein (HDL-C), in male and female rats exposed to ethanol versus untreated intoxicated ones. The plant also pronouncedly attenuated the increases in serum cardiac damage biomarkers, namely lactate dehydrogenase (LDH) and creatine phosphokinase (CPK) compared with ethanol intoxicated untreated rats. In conclusion, this study showed that Panax ginseng has a beneficial impact against ethanol induced hyperlipidemia as a risk element for cardiovascular illness.