Maximum carotid intima-media thickness and NT-pro BNP in association with retinal vein occlusion

Abstract

The purpose is to clarify the relationship between patients with retinal vein occlusion (RVO), maximal intima-media complex thickness (Max IMT), and N-terminal pro-brain natriuretic peptide (NT-proBNP), which is useful in assessing atherosclerosis. This was a retrospective observation, single center study. The patients were 86 RVO patients (male: female = 43:43, mean age 63.3 years), 25 with central retinal vein occlusion (CRVO) and 61 with branch retinal vein occlusion (BRVO), classified as ≥50 years old and <50 years old, Max IMT≥1.1 and less, NT-pro BNP≥55 and less. Results showed that Max IMT ≥1.1 was significantly more common in both the CRVO and BRVO groups at ≥50 years, and NT-pro BNP ≥55 was significantly more common in the CRVO group. Max IMT≥1.1 was seen in 80% of the BRVO group and in 85% of patients aged ≥50 years. Sixty-eight percent of patients in the CRVO group had Max IMT≥1.1, but none of those < 50 years had Max IMT≥1.1. Fortyeight percent of RVO patients had NT-pro BNP≥55, and significantly more patients had Max IMT≥1.1 than those who did not have NT-pro BNP more than 55 (p = 0.02). Multiple regression analysis with Max IMT as the dependent variable showed that age and NT-pro BNP were significantly associated with RVO (p = 0.015, 0.022). RVO patients were more likely to have a Max IMT≥1.1, which was associated with atherosclerosis. Max IMT and NTpro BNP were also associated with RVO patients, so NT-pro BNP may be a marker of RVO.