HER2 Ile655Val single nucleotide polymorphism in patients with ovarian cancer

Abstract

Background: The associations of HER2 Ile655Val single nucleotide polymorphism with cancer is the subject of controversy. Objectives: The aim of our study was to investigate this polymorphism in patients with ovarian cancer. Patients and Methods: Genomic DNA was extracted from peripheral blood leukocytes of 107 patients and 130 healthy women. HER2 gene polymorphism was assessed by PCR-RFLP. Results: No significant difference was observed in genotype and allele frequency between patient and control groups according to HER2 Ile655Val polymorphism. The disease stage, age and histological type were also not associated with the polymorphism. Conclusions: our data show that HER2 Ile655Val single nucleotide polymorphism is not significantly associated with ovarian cancer onset, histological type, age, and stage of the disease in Iranian patients.