Lack of benefit of intravenous immune globulin in a murine model of group A streptococcal necrotizing fasciitis

Abstract

Penicillin, clindamycin, and intravenous immune globulin (Venoglobulin- S; IVIG) alone and in combination were studied in a murine model of group A streptococcal necrotizing fasciitis. As assessed by bacterial clearance, treatment with IVIG was not significantly different from no treatment. All treatment regimens that contained penicillin or clindamycin were more effective (P