Understanding the role of genetic susceptibility (ACE2 and TMPRSS2) in COVID-19

Abstract

COVID-19-related morbidity and mortality are significantly increased with increasing age and the presence of co-existing health conditions, such as cancer and cardiovascular disease. While most infected people recover, even very young and otherwise healthy patients may unpredictably succumb to this disease. COVID-19 is highly susceptible to Angiotensin-converting enzyme 2 (ACE2) and Transmembrane protease-serine 2 (TMPRSS2) polymorphisms altering the angiotensinogen-ACE2 interactions, such as p. Arg514Gly and its prevalence. The article describes the role of understanding the genetic basis of COVID-19 and its susceptibility to human genes.