Palladium-catalyzed multialkynyl cross-coupling reactions with tetraalkynylindates

Abstract

An efficient Pd-catalyzed multialkynyl cross-coupling reaction performed with tetraalkyriylindates generated in situ from the reaction of 1 equiv. of indium trichloride with 4 equiv. of organometallic reagents has been developed to produce symmetric as well as unsymmetric multialkynyl-substituted aromatic compounds in good-to-excellent yields. In these reactions, the four acetylide groups in the tetraalkynylindates transferred effectively to a variety of aryl bromides. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.