Computational Study of a Fractional-Order HIV Epidemic Model with Latent Phase and Treatment

Abstract

In this work, we propose and investigate a model of the dynamical behavior of HIV/AIDS transmission by considering a new compartment of the population with HIV: the latent asymptomatic class. The infection reproduction number that stabilizes the global dynamics of the model is evaluated. We analyze the model’s global asymptotic stability using the Lyapunov function and LaSalle’s invariance principle. To identify the primary factors affecting the dynamics of HIV/AIDS, a sensitivity analysis of the model parameters is conducted. We also examine a fractional-order HIV model using the Caputo fractional differential operator. Through qualitative analysis and applications, we determine the existence and uniqueness of the model’s solutions. We derive some results from the fixed-point theorem and Ulam–Hyers stability. Ultimately, the obtained numerical simulation results are in agreement with the analytical outcomes obtained from the model analysis. Our findings illustrate the efficacy of the fractional model in depicting the dynamics of the HIV/AIDS epidemic and offering critical insights for the formulation of effective control strategies. The results show that early intervention and treatment in the latent phase of infection can decrease the spread of the disease and its progression to AIDS, as well as increase the success of treatment strategies.