mir-218-2 promotes glioblastomas growth, invasion and drug resistance by targeting CDC27

20Citations
Citations of this article
16Readers
Mendeley users who have this article in their library.

Abstract

Glioma has become a significant global health problem with substantial morbidity and mortality, underscoring the importance of elucidating its underlying molecular mechanisms. Recent studies have identified mir-218 as an anti-oncogene; however, the specific functions of mir-218-1 and mir-218-2 remain unknown, especially the latter. The objective of this study was to further investigate the role of mir-218-2 in glioma. Our results indicated that mir-218-2 is highly overexpressed in glioma. Furthermore, we showed that mir-218-2 is positively correlated with the growth, invasion, migration, and drug susceptibility (to β-lapachone) of glioma cells. In vitro, the overexpression of mir-218-2 promoted glioma cell proliferation, invasion, and migration. In addition, the overexpression of mir-218-2 in vivo was found to increase glioma tumor growth. Accordingly, the inhibition of mir-218-2 resulted in the opposite effects. Cell division cycle 27 (CDC27), the downstream target of mir- 218-2, is involved in the regulation of glioma cells. Our results indicate that the overexpression of CDC27 counteracted the function of mir-218-2 in glioma cells. These novel findings provide new insight in the application of mir-218-2 as a potential glioma treatment.

Cite

CITATION STYLE

APA

Feng, Z., Zhang, L., Zhou, J., Zhou, S., Li, L., Guo, X., … Huang, F. (2017). mir-218-2 promotes glioblastomas growth, invasion and drug resistance by targeting CDC27. Oncotarget, 8(4), 6304–6318. https://doi.org/10.18632/oncotarget.13850

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free