Corroles: Acid-Catalysis leading to meso-substituted corroles

Abstract

The use of acid catalysis is an important requirement, being effective both on the synthesis of porphyrins as well as for meso-substituted corroles. The acid catalyst is responsible for protonation of the carbonyl group of aldehydes, which are attacked in an aromatic electrophilic substitution by pyrrole, which leads to the formation of the tetrapyrrolic chain. Another determining factor in the corrole formation is about of the acid type used for these compounds synthesis. This In Focus manuscript reviews the procedures of the synthesis of meso-substituted corroles using different methodologies in the presence of different types of acid catalysts or without acid.