Current understanding of the Trypanosoma cruzi-cardiomyocyte interaction

Abstract

Trypanosoma cruzi, the etiological agent of Chagas disease, exhibits multiple strategies to ensure its establishment and persistence in the host. Although this parasite has the ability toinfectdifferentorgans, heartimpairmentisthemostfrequentclinicalmanifestationofthe disease. Advances in knowledge of T. cruzi-cardiomyocyte interactions have contributed to a better understanding of the biological events involved in the pathogenesis of Chagas disease. This brief review focuses on the current understanding of molecules involved in T. cruzi-cardiomyocyte recognition, the mechanism of invasion, and on the effect of intracellular development ofT. cruzi on the structural organization and molecular response of the target cell. © 2012 Calvet, Melo, Gar-zoni, Oliveira Jr., Silva Neto, Meirelles and Pereira.