Reaktive neutrophile Dermatosen

Abstract

Reactive neutrophilic dermatoses like pyoderma gangrenosum or Sweet's syndrome describe distinct entities associated by similar pathologic characteristics. Histologic examination reveals a dense epidermal and/or dermal inflammatory infiltrate composed of neutrophils. Typically, there is also an increased amount of neutrophiles in the peripheral blood and sometimes association with systemic inflammatory diseases. Common associated conditions are chronic inflammatory bowel disease, autoimmune and collagen vascular diseases and hematologic malignancies. Time of manifestation is often associated with exacerbation of the underlying disease. The exact pathogenesis of reactive neutrophilic dermatoses is still unknown, but these disorders typically respond to antiinflammatory therapies, especially to anti-TNF- based therapeutic approaches.