Effects of intensive lifestyle intervention and gastric bypass on aortic stiffness: A 1-year nonrandomized clinical study

Abstract

Objective To compare the long-term effects of Roux-en-Y gastric bypass (GBS) and intensive lifestyle intervention (ILI) on aortic stiffness. Methods Nonrandomized clinical trial. Aortic stiffness was assessed by carotid-femoral pulse wave velocity (cfPWV) using high-fidelity applanation tonometry. Results A total of 159 treatment-seeking morbidly obese patients were included, 82 (54 females) in the GBS-group and 77 (48 females) in the ILI-group. Participants in the GBS-group were younger (42.0-±-9.9 vs. 46.4-±-10.5 years), heavier (BMI 45.7-±-5.3 vs. 42.0-±-4.9 kg/m2), and had lower systolic pressure (137-±-19 vs. 145-±-18 mm Hg) and pulse pressure (57-±-16 vs. 65-±-17 mm Hg), all P-≤-0.006. Mean (SD) cfPWV at baseline was 8.6-±-1.7 m/s in the GBS-group and 8.6-±-1.9 m/s in the ILI-group, P-=-0.959. At follow-up, mean (95% CI) weight loss was larger in the GBS-group than in the ILI-group -43.3 (-46.0 to -40.7) vs. -12.1 (-14.6 to -9.6) kg, P-