In vitro investigation of laser-induced microgrooves on titanium surface

Abstract

We developed a surface design that imitates the osteon structure of human bone tissue to improve the bio-integration of a titanium implants. Two types of subcellular-sized microgrooves were formed on VT6 (analogue 6Al-4V) titanium surface by laser processing: closed and open microgrooves. An in vitro study of the proliferation of human bone marrow mesenchymal stem cells on the formed structures was carried out, osteogenic differentiation was studied.