Risk assessment based on FDG-PET imaging in patients with synovial sarcoma

Abstract

Synovial sarcoma generally is associated with poor prognosis. With recent advances in molecular biology, it has become apparent not all synovial sarcomas share the same tumor biology. 18 F-fluorodeoxyglucose positron emission tomography (FDG-PET) is useful for risk assessment in several types of sarcomas. We therefore assessed the clinical value of 18 F-FDG-PET- derived maximum standard uptake value (SUV max ) for predicting survival in patients with synovial sarcoma. 18 F-FDG-PET was performed in 44 patients with synovial sarcoma before therapy and resection. SUV max was calculated for each tumor and then evaluated for prognostic usefulness along with metastasis at presentation, tumor grade, histopathologic subtype, age, gender, postsurgical margins, anatomic location, and tumor size for overall survival and progression-free survival. SUV max ranged from 1.2 to 13.0 (median, 4.35). Pretherapy tumor SUV max predicted overall survival and progression-free survival. Patients presenting with a SUV max greater than 4.35 had a decreased disease-free survival and were therefore at high risk for having local recurrences and metastatic disease. Level of Evidence: Level I, diagnostic study. See the Guidelines for Authors for a complete description of levels of evidence. © 2008 The Association of Bone and Joint Surgeons.