Serum albumin and cerebro-cardiovascular mortality during a 15-year study in a community-based cohort in Tanushimaru, a cohort of the seven countries study

19Citations
Citations of this article
29Readers
Mendeley users who have this article in their library.

Abstract

Objective There is little long-term data on the association between the serum albumin levels and mortality in community-based populations. We aimed to determine whether the serum albumin level is an independent risk factor for all-cause and cause-specific death in a community-based cohort study in Japan. Methods In 1999, we performed a periodic epidemiological survey over a 15-year period in a population of 1,905 healthy subjects (783 males, 1,122 females) who were older than 40 years of age and who resided in Tanushimaru, a rural community, in Japan. Over the course of the study, we periodically examined the blood chemistry of the study subjects, including their serum albumin levels. Their baseline serum albumin levels were categorized into quartiles. Results The baseline albumin levels were significantly associated with age (inversely), body mass index (BMI), diastolic blood pressure, lipid profiles [high density lipoprotein-cholesterol (HDL-c), low-density lipoprotein-cholesterol (LDL-c) and triglycerides] and estimated glomerular filtration rate (eGFR). After adjusting for confounders, a Cox proportional hazards regression analysis demonstrated that a low serum albumin level was an independent predictor of all-cause death [hazard ratio (HR): 0.39, 95% confidence interval (CI): 0.24-0.65], cancer death (HR: 0.43, 95% CI: 0.18-0.99), death from infection (HR: 0.21, 95% CI: 0.06-0.73) and cerebro-cardiovascular death (HR: 0.19, 95% CI: 0.06-0.63). The HRs for all-cause and cerebrocardiovascular death in the highest quartile vs. the lowest quartile of albumin after adjusting for confounders were 0.59 (95%CI:0.39-0.88) and 0.15 (95%CI: 0.03-0.66), respectively. Conclusion The serum albumin level was thus found to be a predictor of all-cause and cerebrocardiovascular death in a general population.

Author supplied keywords

References Powered by Scopus

Revised Equations for Estimated GFR From Serum Creatinine in Japan

5314Citations
N/AReaders
Get full text

The atherosclerosis risk in communit (aric) stui)y: Design and objectwes

0
3076Citations
N/AReaders
Get full text

Serum Albumin Level and Physical Disability as Predictors of Mortality in Older Persons

578Citations
N/AReaders
Get full text

Cited by Powered by Scopus

New insights about albumin and liver disease

133Citations
N/AReaders
Get full text

Critical appraisal of the role of serum albumin in cardiovascular disease

117Citations
N/AReaders
Get full text

Low serum albumin: A neglected predictor in patients with cardiovascular disease

88Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Umeki, Y., Adachi, H., Enomoto, M., Fukami, A., Nakamura, S., Nohara, Y., … Fukumoto, Y. (2016). Serum albumin and cerebro-cardiovascular mortality during a 15-year study in a community-based cohort in Tanushimaru, a cohort of the seven countries study. Internal Medicine, 55(20), 2917–2925. https://doi.org/10.2169/internalmedicine.55.6931

Readers' Seniority

Tooltip

Researcher 5

45%

Professor / Associate Prof. 3

27%

PhD / Post grad / Masters / Doc 3

27%

Readers' Discipline

Tooltip

Medicine and Dentistry 11

69%

Nursing and Health Professions 3

19%

Biochemistry, Genetics and Molecular Bi... 1

6%

Immunology and Microbiology 1

6%

Save time finding and organizing research with Mendeley

Sign up for free