Vascular β-adrenergic receptor adenylyl cyclase system from renin- transgenic hypertensive rats

Abstract

In transgenic rats harboring the mouse Ren-2(d) gene [TG(mREN2)27], downregulation of the myocardial β-adrenergic receptor adenylyl cyclase system has been demonstrated previously. Because a reduced vasodilatory reactivity may significantly contribute to hypertension in this model of an activated tissue renin-angiotensin system, the present study investigated alterations of the vascular β-adrenergic receptor adenylyl cyclase system. In freshly harvested aortas from transgenic rats, the activity of adenylyl cyclase was reduced significantly (P