Congenital hypogonadotropic hypogonadism with early-onset coronary artery disease

Abstract

The patient with congenital hypogonadotropic hypogonadism (HH) shows low serum levels of andro-gen, which is a group of sex hormones including testosterone, caused by the decreased gonadotropin release in the hypothalamus. Recent reports showed androgens exert protective effects against insulin resistance or ath-erosclerotic diseases, such as diabetes mellitus or coronary artery disease. However, whether the juvenile hypo-gonadism affects the diabetes or cardiovascular disease is unclear. We report a case of a middle-aged man with congenital HH who had severe coronary artery disease complicated with metabolic disorders. J. Med. Invest. 68: 189-191, February, 2021.