Palladium catalyzed synthesis of heterocycles

Abstract

Novel procedures of constructing heterocycles are described which employ palladium catalyzed intramolecular addition of amino or hydroxyl group to an acetylene bond as a key reaction. Pyrroles and furans are prepared from l-amino-3-alkyn-2-ols and 3-alkyne-1,2-diols, respectively. Successive addition of two hydroxyl groups to one acetylene bond gives various types of acetals. Insect pheromones containing intramolecular acetal linkage are produced by applying this reaction. © 1983 IUPAC