ANALISIS IN SILICO SENYAWA HIBISCETIN KOMBUCHA ROSELLA SEBAGAI IMUNOMODULATOR SEL IMUNOKOMPETEN PADA PENYAKIT MALARIA

Abstract

Malaria is one of the public health problems in Indonesia. The data show that drug resistance is found in malaria control. For this reason, various efforts are needed to find solutions to overcome these problems. The presence of the flavonoid compound hibiscetin in Kombucha Rosella is thought to act as an immunomodulator that can increase the activity and proliferation of lymphocyte cells during malaria infection. Kombucha Rosella is considered to be a supportive therapy for malaria treatment. The purpose of this study was to obtain a scientific basis for the use of Kombucha Rosella tea as immunotherapy for malaria. The method used is by using An silico docking simulation. The ligand compound used was hibiscetin and the target protein was TCR-MHC II complex. Docking simulation using AutodockTools 1.5.6, Autodock 4.2, and Discovery Studio Visualizer applications. The results showed that the Hibisctin compound had the potential to increase the activity of immunocompetent cells in silico with the value of Free Energy Binding (∆Gbinding)-3.08, the value of the inhibition constant was 5.49 nM, and the RMSD value <5 was 3.32.