Correction of disordered mineral bone metabolism in patients affected by chronic periodontitis

Abstract

One of the main mechanisms in pathogenesis of chronic periodontitis is disordered bone metabolism that is accomplished by cortical plate's resorption, destruction of the interdental septums and osteoporosis of the jaws. Administration of osteotropic agents will allow achieving efficient results in treatment of the patients affected by periodontal disorders, lower the tendency of bone resorption and stimulate the processes of regeneration. The article demonstrates the results obtained after the surgical treatment of the patients with osteopenia affected by chronic periodontitis of II-III degree that were administered simultaneously with synthetic osteoplastic material Tricalcium phosphate and a bone resorption inhibitor Ibandronic acid. It has been established the high efficiency of the recommended treatment that was proved by positive progress of biochemical markers of bone metabolism in blood serum and urine of the individuals from the main group taken 24 month after the beginning of the treatment. The study shows that the reis arise of osteocalcin by 11,5% in the blood serum of the main group patients 2 years after the research and the amount of desoxypiridynolin, on the other hand, was by 21,72% lower comparing with those from the main group (r < 0,05).