Preexposure Prophylaxis for HIV — Where Do We Go from Here?

Abstract

Transmission of the human immunodeficiency virus (HIV) continues at a staggering rate in many areas of the world. The rate of HIV acquisition in young, healthy adults (mostly women) was 3 to 5 per 100 person-years in two trials studying heterosexual transmission of HIV in sub-Saharan Africa, now reported in the Journal (the Preexposure Prophylaxis Trial for HIV Prevention among African Women [FEM-PrEP]1 and the TDF2 study2). This rate of HIV transmission demands the urgent development of new prevention strategies as well as the deployment of all existing strategies, including the use of condoms, male circumcision, and the treatment . . .