adaptr: an R package for simulating and comparing adaptive clinical trials

Abstract

The adaptr R package facilitates simulation and comparison of adaptive clinical trial designs using Bayesian statistical methods. The package supports a flexible number of arms, use of a common control arm, pre-specified and user-defined outcomeand posterior probability distribution-generating functions, fixedand response-adaptive randomisation (RAR), various adaptation rules for arm dropping and stopping, calculation of trial design performance metrics, and visualisation of results. Simulations are relatively fast, can run in parallel, and can be reloaded from previous sessions.