Role of promyelocytic leukemia zinc finger (PLZF) in cell proliferation and cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) Gene repression

Abstract

Background: Promyelocytic leukemia zinc finger (PLZF) is transcription repressor that recruits nuclear co-repressors at the target promoters. PLZF is overexpressed in various human solid tumors, such as clear cell renal carcinoma, glioblastoma, and seminoma. Results: PLZF represses transcription of CDKN1A by inhibition of p53 acetylation, Sp1 binding. Conclusion: PLZF causes cellular transformation and increases cell proliferation by repressing transcription of CDKN1A. Significance: PLZF can act as a proto-oncogene depending on the cell types. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.