Effect of cinnamtannin B-1 on cholecystokinin-8-evoked responses in mouse pancreatic acinar cells

Abstract

10-10 molL). Finally, the anti-oxidant protected acinar cells against CCK-8-induced cell death. 4. The beneficial effects of cinnamtannin B-1 appear to be mediated by a reduction in intracellular Ca2+ overload, ROS production and intracellular accumulation of digestive enzymes, which is a common pathological precursor that mediates pancreatitis. © 2010 Blackwell Publishing Asia Pty Ltd.