Introduction: Vitamin D deficiency is a common health problem. Vitamin D supplements are used to improve vitamin D status; however, there are contradictory data related to what doses to give and how often they should be given. Many studies have investigated the effects of vitamin D supplementation on muscle strength, but the results remain controversial. We aimed to compare the effects and safety of single high-dose with daily low-dose oral colecalciferol on 25(OH)D levels and muscle strength in postmenopausal women with vitamin D deficiency or insufficiency. Methods and design: Sixty healthy postmenopausal women who had serum vitamin D levels <20ng/mL (50nmol/L) were enrolled in the study. Group 1 (n=32) was given daily oral dosages of 800IU vitamin D3, and group 2 (n=28) was given a single oral dose of 300,000IU vitamin D3. Serum vitamin D levels and muscle strengths were measured at the beginning, 4th, and 12th week. Muscle strength tests were performed at 60° using a Biodex system 3 isokinetic dynamometer. Results: Pretreatment vitamin D levels did not differ between the two groups (10.2±4.4ng/mL (25,4±10,9nmol/L); 9.7±4.4ng/mL (24,2±10,9nmol/L), p>0.05). A significant increase in vitamin D levels was observed in both groups at 4 and 12weeks after vitamin D3 treatment. The increase in the single-dose group was significantly higher than the daily low-dosage group at the 4th week (35.9±9.6ng/mL (89,6±23,9nmol/L), 16.9±5.8ng/mL (42,1±14,4nmol/L), p=0.01). The increase in the single-dose group was significantly higher than in the daily low dosage group at the 12th week (23.4±4.7ng/mL (58,4±11,7nmol/L), 19.8±7.2ng/mL (49,4±17,9nmol/L), p=0.049). The quadriceps muscle strength score increased significantly in the daily group at the 4th week (p=0.038). The hamstring muscle strength score increased significantly in the daily group at the 12th week (p=0.037). Conclusion: Although daily administration routes are more effective in improving muscle strength, a single administration is more effective in increasing vitamin D levels.
CITATION STYLE
Apaydin, M., Can, A. G., Kizilgul, M., Beysel, S., Kan, S., Caliskan, M., … Cakal, E. (2018). The effects of single high-dose or daily low-dosage oral colecalciferol treatment on vitamin D levels and muscle strength in postmenopausal women. BMC Endocrine Disorders, 18(1). https://doi.org/10.1186/s12902-018-0277-8
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