Ligand-enabled ni-catalyzed enantioselective hydroarylation of styrenes and 1,3-dienes with arylboronic acids

Abstract

We report an enantioselective hydroarylation reaction of styrenes and 1,3-dienes with arylboronic acids catalyzed by nickelcomplexes bearing chiral spiro aminophosphine ligands. The reaction serves as an efficient, straightforward, and mildmethod for the preparationof enantioenriched1,1-diarylalkanes, which are important building blocks for the synthesis of many biologically active molecules. This redox neutral reaction uses only catalytic amounts of the reagents and is, therefore, atom economical and environmentally benign.