Abstract
Background: Heparan sulfate colocalizes with amyloid-β in senile plaques of Alzheimer disease. Results: Overexpression of the heparan sulfate-degrading enzyme (heparanase) lowers the amyloid burden in a transgenic mouse model of Alzheimer disease. Conclusion: Heparan sulfate modulates amyloid-β deposition. Significance: We present the first direct in vivo proof that heparan sulfate actively participates in senile plaque formation.
Cite
CITATION STYLE
Jendresen, C. B., Cui, H., Zhang, X., Vlodavsky, I., Nilsson, L. N. G., & Li, J. P. (2015). Overexpression of heparanase lowers the amyloid burden in amyloid-β precursor Protein Transgenic mice. Journal of Biological Chemistry, 290(8), 5053–5064. https://doi.org/10.1074/jbc.M114.600569
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
