A rhelogical separator for very large DNA molecules

Abstract

We present a rheological separation method for DNA molecules in which their deformability is used to advantage. This is the "radial migration method"; here we present experimental verification of the principle, theory having been reported elsewhere. The main conclusions are: (1) the theory is reasonably good; (2) radial migration is highly sensitive to the molecular weight, as predicted, and (3) intact T2 DNA (1.25 × 108 daltons) can be made to migrate about three centimeters in less than three hours. © 1979 Information Retrieval Limited.