In vivo study of tetraprenyltoluquinone, an anticancer compounds from garcinia cowa roxb

Abstract

Objective: To investigate the in vivo antitumor effect of TPTQ against H-460 lung cancer cell lines in nude mice. Materials and Methods: Female nude mice bearing H-460 tumor at size approximately 5 mm in diameter were treated with a single intraperitoneal dose 800 mg/kg of TPTQ. The vehicle-Treated (10% tween 80) animals were used as control group. The tumor size and mice body weight were measured for 14 days. Results: Single treatment of 800 mg/kg of TPTQ displayed moderate antitumor activity against H-460 tumor xenografts as compared with vehicle-Treated control. The mean time to reach RTV of 4 for vehicle-Treated control group was 4.5 days whereas for TPTQ-Treated (800 mg/kg) group was 9.5 days. Conclusion: The results showed that TPTQ slowed the tumor growth by 5 days. Thus, TPTQ may be considered as a promising compound in cancer chemotherapy.