One-stage anterior approach for four-vessel occlusion in rat

Abstract

Background and Purpose - We report a modified 4-vessel occlusion (4VO) rat model. Method - We used a 1-stage anterior approach for making bilateral hemispheric ischemia. Results - Modified 4VO method decreased cerebral blood flow to 12% to 14% of baseline levels. Conclusion - This modified 4VO method is a minimally invasive, quick, reliable procedure for producing ischemic changes. © 2005 American Heart Association, Inc.